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Updated: Sep 29, 2025
04:24
Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
Published on: September 5, 2025
102
Application Site Reactions from the Buprenorphine Transdermal Patch: A Case Series.
Journal of Pain & Palliative Care Pharmacotherapy
|March 25, 2022
Summary
Four patients experienced skin reactions to high-strength buprenorphine transdermal patches (BTP), leading to treatment changes. Some patients tolerated buprenorphine buccal films (BBF) despite BTP site reactions.
Area of Science:
- Pharmacology
- Dermatology
- Pain Management
Background:
- Buprenorphine transdermal patch (BTP) is used for chronic pain.
- Transdermal patches can cause application site reactions (ASRs).
- ASRs with BTP are typically infrequent and rarely require discontinuation.
Purpose of the Study:
- To describe ASRs in four patients using the BTP.
- To investigate potential dose-response relationships in BTP-induced ASRs.
- To assess tolerability of alternative buprenorphine formulations.
Main Methods:
- Case series of four patients experiencing ASRs to BTP.
- Detailed description of reaction characteristics and onset.
- Evaluation of patient response to buprenorphine buccal films (BBF).
Main Results:
- Four patients developed erythematous, rash-like ASRs to BTP.
- ASRs occurred at BTP strengths of 10 mcg/hr or higher.
- Three patients tolerated BBF before or after experiencing BTP ASRs.
Conclusions:
- BTP can cause ASRs, potentially related to dose and delayed hypersensitivity.
- Higher BTP strengths may increase ASR risk.
- BBF may be a viable alternative for patients with BTP-related skin reactions.
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