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A Systematic Review of European Clinical Practice Guidelines for Respiratory Syncytial Virus Prophylaxis

Rachel M Reeves1, Maarten van Wijhe2, Toni Lehtonen3,4

  • 1Centre for Global Health, University of Edinburgh, Edinburgh, United Kingdom.

The Journal of Infectious Diseases
|March 25, 2022
PubMed

Insights

This systematic review identified 20 European clinical practice guidelines for preventing respiratory syncytial virus (RSV) infection. Key findings highlight variations in palivizumab prophylaxis recommendations, particularly for premature infants.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Widespread palivizumab prophylaxis use has led to numerous clinical practice guidelines (CPGs) for respiratory syncytial virus (RSV) prevention in Europe.
  • A systematic review was conducted to identify these European CPGs for RSV infection prevention.

Purpose of the Study:

  • To systematically identify and analyze clinical practice guidelines (CPGs) for respiratory syncytial virus (RSV) prevention across Europe.
  • To assess the reporting quality and identify discrepancies in recommendations among identified CPGs.

Main Methods:

  • A systematic literature search was performed, including contacting European influenza and respiratory virus networks and public health institutions.
  • The Reporting Items for practice Guidelines in Healthcare (RIGHT) Statement checklist was used for data extraction and quality review.

Main Results:

  • Twenty national CPGs published between 2000 and 2018 were identified.
  • Significant discrepancies exist in palivizumab prophylaxis recommendations for premature infants based on gestational age.
  • Palivizumab was recommended or considered for infants with bronchopulmonary dysplasia, congenital heart disease (85%), and severe combined immunodeficiency (60%).

Conclusions:

  • Agencies should adopt RIGHT reporting requirements for future RSV prevention guidelines.
  • Improved reporting will enhance the evidence base for decision-making in RSV prevention strategies.
Abstract

Keywords:
RSV guidelines Europepalivizumabprophylaxis

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