Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

Major Hormones and Their Functions

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

The Endocrine System

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...

Structures of the Endocrine System

Structures of the Endocrine System

The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...

Regulation of Hormone Secretion

Regulation of Hormone Secretion

Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Approach to the patient: Precision Medicine-Guided Evaluation and Treatment of Acromegaly.

The Journal of clinical endocrinology and metabolism·2026

Same author

Evaluation of temporal muscle thickness in subjects with acromegaly: a follow-up study.

Therapeutic advances in endocrinology and metabolism·2026

Same author

Consensus on acromegaly complications: an update.

Pituitary·2026

Same author

Acromegaly and Cardiovascular Disease: Mechanisms, Clinical Impact, and Evolving Management.

Endocrine reviews·2026

Same author

Transfer entropy characterization of causal relations in heat transport near equilibrium.

Physical review. E·2026

Same author

Cost-effectiveness of personalized medical treatment in acromegaly: a post hoc analysis of the ACROFAST study.

Journal of the Endocrine Society·2026

Search research articles

Related Experiment Video

Updated: Sep 29, 2025

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

ENDOCRINE OBESITY: Pituitary dysfunction in obesity.

Sabina Ruiz¹, Federico Vázquez¹, Silvia Pellitero¹

¹Department of Endocrinology and Nutrition, Germans Trias i Pujol University Hospital and Research Institute, Badalona, Catalonia, Spain.

European Journal of Endocrinology

|March 25, 2022

Summary

Obesity causes pituitary gland dysfunction through adaptive and maladaptive changes in hypothalamic-pituitary axes. Understanding these mechanisms is key to treating obesity-related hormonal issues.

More Related Videos

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Related Experiment Videos

Last Updated: Sep 29, 2025

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Area of Science:

Endocrinology
Metabolic disorders
Neuroendocrinology

Background:

Obesity is a global pandemic linked to multi-organ dysfunction.
The pituitary gland is susceptible to obesity-induced metabolic changes.
Obesity triggers hypothalamic-pituitary axis alterations, initially adaptive, then maladaptive.

Purpose of the Study:

To review current knowledge on obesity-related pituitary dysfunction.
To explore the pathogenic mechanisms involved.
To discuss potential therapeutic strategies for severe obesity.

Main Methods:

Literature review of recent research on obesity and pituitary function.
Analysis of pathogenic mechanisms linking obesity to pituitary dysfunction.
Discussion of therapeutic interventions.

Main Results:

Obesity leads to functional modifications in hypothalamic-pituitary axes.
These modifications can become maladaptive, perpetuating obesity and hormonal symptoms.
Specific pituitary dysfunctions are associated with obesity's metabolic impact.

Conclusions:

Obesity significantly impacts pituitary gland function.
Understanding obesity-related pituitary dysfunction is crucial for effective treatment.
Targeting pituitary dysfunction may offer new therapeutic avenues for severe obesity.