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ATYPICAL ENDOGENOUS FUNGAL ENDOPHTHALMITIS CAUSED BY CANDIDA RUGOSA.

Ryohei Koide1,2, Soichiro Yamamoto1,2, Yoshiyuki Kobayashi1

  • 1Department of Ophthalmology, Faculty of Medicine, Saga University, Saga-849-8501, Japan.

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This summary is machine-generated.

This case report details a rare fungal endophthalmitis caused by Candida rugosa. DNA analysis proved effective in diagnosing this invasive candidiasis case.

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Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Endogenous fungal endophthalmitis is a severe intraocular infection.
  • Nonalbicans Candida species are increasingly recognized as opportunistic pathogens.
  • Candida rugosa is a rare cause of invasive candidiasis.

Observation:

  • A 45-year-old woman undergoing breast cancer treatment presented with decreased visual acuity and vitreous opacity.
  • Initial diagnostic tests, including blood work and imaging, were inconclusive.
  • Fungal endophthalmitis caused by Candida rugosa was suspected based on clinical presentation.

Findings:

  • Vitrectomy enabled sample collection for definitive diagnosis.
  • DNA analysis of the lesion sample using Basic Local Alignment Search Tool identified Candida rugosa.
  • Standard blood tests and cultures were negative for fungal infection.
  • The patient's visual acuity improved post-vitrectomy.

Implications:

  • This case highlights the importance of considering rare Candida species in endogenous fungal endophthalmitis.
  • DNA analysis is a valuable tool for diagnosing challenging fungal infections.
  • Early diagnosis and treatment are crucial for visual outcomes in fungal endophthalmitis.