Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glial Cells01:04

Glial Cells

89.8K
Overview
89.8K
The Blood-brain Barrier00:49

The Blood-brain Barrier

49.5K
Overview
49.5K
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

4.3K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
4.3K
Cerebrospinal Fluid01:21

Cerebrospinal Fluid

3.2K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
3.2K
Protein Glycosylation01:25

Protein Glycosylation

7.5K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
7.5K
Glycosaminoglycans01:23

Glycosaminoglycans

5.2K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Large glycomics datasets as a tool to understand the function of glycans.

Nature chemical biology·2026
Same author

Adaptive evolution of gene regulatory networks in mammalian neocortex.

Nature·2026
Same author

Quantitative Modeling of IgG N-Glycosylation Profiles from Population Data.

International journal of molecular sciences·2025
Same author

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.

Nature communications·2025
Same author

Invigorating discovery and clinical translation of aging biomarkers.

Nature aging·2025
Same author

Specification of claustro-amygdalar and palaeocortical neurons and circuits.

Nature·2025

Related Experiment Video

Updated: Sep 29, 2025

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
07:52

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

8.8K

The dynamic brain N-glycome.

Thomas S Klarić1, Gordan Lauc2,3

  • 1Genos Glycoscience Research Laboratory, Zagreb, Croatia. tklaric@genos.hr.

Glycoconjugate Journal
|March 25, 2022
PubMed
Summary
This summary is machine-generated.

The brain's N-glycome, or the complete set of N-glycans, is more dynamic than previously thought. This neuroglycome plasticity offers potential therapeutic targets for reversing pathological changes in the brain.

Keywords:
BrainN-glycansN-glycomeN-glycosylationNeuroglycome

More Related Videos

Ganglioside Extraction, Purification and Profiling
10:05

Ganglioside Extraction, Purification and Profiling

Published on: March 12, 2021

4.8K
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.3K

Related Experiment Videos

Last Updated: Sep 29, 2025

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
07:52

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

8.8K
Ganglioside Extraction, Purification and Profiling
10:05

Ganglioside Extraction, Purification and Profiling

Published on: March 12, 2021

4.8K
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.3K

Area of Science:

  • Neurobiology
  • Glycomics
  • Biochemistry

Background:

  • Glycosylation, the attachment of carbohydrates to macromolecules, is a key regulatory mechanism.
  • Asparagine-linked glycosylation (N-glycosylation) is crucial for vertebrate brain development and function.
  • The brain N-glycome's complexity and variability were previously underestimated.

Purpose of the Study:

  • To analyze the collective impact of large-scale changes in the brain N-glycome.
  • To understand the role of N-glycans in neurobiology.
  • To explore the plasticity of the neuroglycome.

Main Methods:

  • Advanced N-glycomics analysis of brain tissue.
  • Comprehensive characterization of the brain N-glycome under various conditions.
  • Systematic study of N-glycan structures and their variations.

Main Results:

  • The brain N-glycome is more dynamic and adaptable than previously recognized.
  • N-glycans can change in response to intrinsic and extrinsic stimuli.
  • Factors like neurodevelopment, aging, diet, stress, and disease significantly alter the N-glycome.

Conclusions:

  • The neuroglycome exhibits significant, underappreciated plasticity.
  • This plasticity suggests potential therapeutic strategies for reversing pathological brain changes.
  • N-glycomics is a valuable analytical method with ongoing advancements and limitations.