Related Experiment Video
Updated: Sep 29, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Hypertension and Dyslipidemia Combined Therapeutic Approaches
Claudio Borghi1,2, Federica Fogacci3,4, Davide Agnoletti3,4
1Medical and Surgical Sciences Department, Hypertension and Cardiovascular Risk Factors Research Center, Sant'Orsola-Malpighi University Hospital, U.O. Medicina Interna Cardiovascolare, Alma Mater Studiorum University of Bologna, Via Albertoni, 15, 40138, Bologna, Italy. claudio.borghi@unibo.it.
Insights
Managing total cardiovascular risk by addressing both blood pressure and lipid levels offers greater benefits than treating blood pressure alone. This review explores effective non-pharmacological and pharmacological strategies for simultaneous hypertension and dyslipidemia management.
Area of Science:
- Cardiology
- Metabolic Syndrome Research
- Pharmacology
Background:
- Isolated blood pressure management offers limited cardiovascular risk reduction.
- Concurrent hypertension and dyslipidemia necessitate comprehensive risk management strategies.
- Metabolically neutral antihypertensives and statins show promise in combined therapy.
Purpose of the Study:
- To review evidence on non-pharmacological and pharmacological interventions for managing both blood pressure and lipid levels.
- To highlight approaches that favorably impact both hypertension and dyslipidemia.
- To inform strategies for reducing overall cardiovascular disease risk.
Main Methods:
- Literature review of existing studies.
- Analysis of evidence on combined treatment effects.
- Synthesis of data on non-pharmacological and pharmacological interventions.
Main Results:
- Combined treatment of hypertension and dyslipidemia significantly reduces cardiovascular disease risk.
- Non-pharmacological approaches demonstrate efficacy in managing both conditions.
- Specific antihypertensive drugs and statins offer a dual benefit.
Conclusions:
- Integrated management of blood pressure and lipids is crucial for cardiovascular health.
- Non-pharmacological and selected pharmacological strategies provide synergistic benefits.
- This review consolidates evidence for optimizing total cardiovascular risk reduction.
Abstract:
Treating blood pressure (BP) alone may provide only limited benefits while it is recommendable to manage the total cardiovascular risk. To date, several studies have shown that concomitant treatment of hypertension and dyslipidemia with non-pharmacological approaches and/or metabolically neutral antihypertensive drugs and statins produce a significantly greater reduction of the risk of developing cardiovascular disease. Thus, in this review article, we summarize the available evidence regarding non-pharmacological and pharmacological approaches with a favourable effect on both BP and lipids.
Related Concept Videos
Atherosclerosis III: Management
Hypertension IV: Drug Therapy and Lifestyle Modifications
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Peripheral Artery Disease III: Interprofessional Care
Coronary Artery Disease V: Interprofessional Care
Heart Failure V: Medical Management

