Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Korbin H J West1, Curran G Gahan2, Patricia R Kierski3

  • 1Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706, USA.

Angewandte Chemie (International Ed. in English)
|March 25, 2022
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MrtR of <i>Mesorhizobium tianshanense</i> reveals both activation and inhibition mechanisms of a LuxR-type quorum sensing receptor.

bioRxiv : the preprint server for biology·2026
Same author

Engineered <i>Bacillus subtilis</i> Systems for the Characterization and Detection of Peptide-Based Quorum Sensing in Gram-Positive Bacteria.

Biochemistry·2026
Same author

Thermotropic liquid crystal droplets stabilized by nanoparticles for the optical detection of phospholipid membranes: impact of membrane composition on LC ordering transitions.

Soft matter·2026
Same author

Synthesis, Characterization, and Polymerization of 4'-Acyl(oxy) Alkenyl Azlactone Monomers Designed Using a Steglich Rearrangement Approach.

Macromolecules·2026
Same author

The Influence of Charge Correlation and Ion Solvation on the Phase Behavior of Single-Ion Conducting Polymer Blend Electrolytes Using SAXS/SANS.

Macromolecules·2026
Same author

A Small Molecule That Inhibits the Quorum Sensing Receptor AgrC in <i>Staphylococcus aureus</i>.

Journal of the American Chemical Society·2026

A novel synthetic peptide effectively blocks bacterial quorum sensing and shows high bioavailability. Controlled release from microparticles significantly enhanced its potency against skin infections in a wound model.

Area of Science:

  • Microbiology
  • Biotechnology
  • Materials Science

Background:

  • Bacterial cell-to-cell communication, known as quorum sensing (QS), regulates virulence factors and biofilm formation.
  • QS is a promising target for antimicrobial strategies to combat infections.
  • Developing effective delivery systems for QS inhibitors is crucial for therapeutic applications.

Purpose of the Study:

  • To investigate a synthetic peptide's ability to inhibit bacterial quorum sensing.
  • To evaluate the efficacy of controlled peptide release from degradable polymeric microparticles for treating bacterial skin infections.

Main Methods:

  • A synthetic peptide targeting bacterial QS was synthesized and characterized.
  • The peptide's bioavailability was assessed in mouse tissue.
Keywords:
Anti-InfectiveCell-Cell SignallingControlled ReleasePeptidesQuorum Sensing

Related Experiment Videos

  • Degradable polymeric microparticles were formulated for controlled peptide release.
  • The efficacy of microparticle-delivered peptide was tested in a bacterial skin wound infection model in mice.

    • Main Results:

    • The synthetic peptide demonstrated potent inhibition of bacterial quorum sensing.
    • High bioavailability of the peptide was confirmed in mouse tissue.
    • Controlled release of the peptide from microparticles significantly enhanced its antimicrobial activity.
    • The microparticle-based delivery system markedly inhibited skin infection in the wound model, outperforming conventional peptide delivery.

    Conclusions:

    • Synthetic peptides targeting QS represent a viable therapeutic strategy against bacterial infections.
    • Degradable polymeric microparticles offer an effective platform for enhanced delivery and efficacy of QS inhibitors.
    • This approach holds potential for improved treatment of bacterial skin infections.