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Updated: Sep 29, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Is hypoimmunogenic stem cell therapy safe in times of pandemics?
Friederike Matheus1, Tal Raveh2, Anthony E Oro3
1Institute for Stem Cell Research, iPSC Core Facility, Helmholtz Zentrum München GmbH, 85764 Neuherberg, Germany.
Abstract:
The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in "universal" human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies.
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