Chemotaxis and cell motility in the cellular slime molds

Chemotaxis and cell motility have essential roles to play throughout the developmental cycle of the cellular slime molds. The particular emphasis of this review, however, will be on the amoeboid stages of the life cycle. The nature of the chemoattractants and their detection will be discussed as will the possible mechanisms that may account for the directed locomotion of amoebae. Intracellular chemoattractant-elicited molecular responses thought to play a role in transduction of extracellular signals into a motility response will also be examined. Furthermore, relationships of these transduction pathway components with changes in assembly states of the cytoskeletal proteins contributing to shape change and cell movement will be assessed. Theories of amoeboid movement involving these cytoskeletal proteins will be compared and discussed in terms of their relevance to cellular slime mold motility.