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Blocking Candida adherence to contact lenses.

S I Butrus, S A Klotz

    Current Eye Research
    |October 1, 1986
    PubMed
    Summary

    Microbial adherence to contact lenses is a key step in infectious keratitis. Tear proteins and lens properties influence yeast adhesion, with worn lenses showing significantly higher adherence.

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    Area of Science:

    • Ophthalmology
    • Microbiology
    • Biomaterials Science

    Background:

    • Contact lens-associated infectious keratitis is a significant clinical concern.
    • Microorganism adherence to contact lenses is a critical initial step in disease pathogenesis.

    Purpose of the Study:

    • To investigate the adherence of Candida albicans to various contact lens types.
    • To determine the influence of lens properties and tear components on yeast adherence.

    Main Methods:

    • Systematic investigation of yeast adherence to hydrophobic and hydrophilic extended-wear contact lenses.
    • Evaluation of the role of tear proteins (albumin, lactoferrin, lysozyme, fibronectin, mucin) and concanavalin A.
    • Comparison of yeast adherence to worn versus unworn contact lenses.

    Main Results:

    • Yeast adherence to hydrophobic lenses correlated with wetting angle; adherence to hydrophilic lenses correlated with water content.
    • Tear proteins (albumin, lactoferrin, lysozyme, fibronectin) enhanced yeast adherence.
    • Mucin significantly reduced yeast adherence to both lens types.
    • Worn hydrophilic extended wear lenses showed a ten-fold greater yeast adherence compared to unworn lenses.

    Conclusions:

    • Lens material properties (hydrophobicity, water content) significantly affect yeast adherence.
    • Tear components, particularly proteins, enhance microorganism adherence to contact lenses.
    • Extended wear increases yeast adherence, highlighting a risk factor for infectious keratitis.

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