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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

745
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
745
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

434
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

550
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Related Experiment Video

Updated: Sep 29, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

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Primary appendiceal diffuse large B-cell lymphoma initially presenting as acute appendicitis: A case report.

Kai-Yuan Liu1, Sheng-Mao Wu2, Wei-Yu Chen3

  • 1Division of Colorectal Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

International Journal of Surgery Case Reports
|March 25, 2022
PubMed
Summary

Primary appendiceal lymphoma (PAL) is a rare cause of acute appendicitis. This case highlights successful treatment of appendiceal diffuse large B-cell lymphoma (DLBCL) with surgery and R-CHOP chemotherapy, achieving complete remission.

Keywords:
Case reportDiffuse large B cell lymphomaPrimary appendiceal lymphomaR-CHOP

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Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), comprising 25% of cases.
  • Primary appendiceal lymphomas (PAL) are exceptionally rare, presenting as acute appendicitis in 0.015% of gastrointestinal lymphomas.

Purpose of the Study:

  • To report a rare case of primary appendiceal diffuse large B-cell lymphoma (DLBCL) initially presenting as acute appendicitis.
  • To illustrate the diagnostic and management pathway for this rare condition.

Main Methods:

  • A 57-year-old male presented with acute appendicitis symptoms, leading to laparoscopic appendectomy.
  • Pathological examination confirmed DLBCL. Staging involved PET/CT and bone marrow biopsy.
  • Treatment consisted of six cycles of R-CHOP chemotherapy.

Main Results:

  • Pathology revealed DLBCL of the appendix with cut-end involvement.
  • Staging identified Ann Arbor Stage II disease; PET/CT and bone marrow biopsy ruled out other involvement.
  • Post-treatment PET/CT showed complete remission; the patient remained stable for 15 months.

Conclusions:

  • PAL is rare and often mimics acute appendicitis.
  • CT characteristics can aid in lymphoma diagnosis; PET/CT is crucial for staging.
  • Surgical resection followed by 6 cycles of R-CHOP-21 is recommended for PAL, irrespective of disease stage.