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Updated: Sep 29, 2025
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Post-mortem histopathology of pituitary and adrenals of COVID-19 patients
Antonia Fitzek1, Moritz Gerling1, Klaus Püschel1
1Institute of Legal Medicine of the University Medical Center Hamburg-Eppendorf, Germany.
Background:
Knowledge of the exact organ manifestation is essential for a comprehensive understanding of COVID-19 infection. Here, the histopathological changes in the pituitary and adrenal glands were analyzed.
Methods:
In this series, the formalin-fixed tissues of 63 pituitary glands and 50 adrenal glands were examined. We performed HE and PAS staining and examined COVID-19 nucleocapsid antibody immunohistochemically in the pituitary glands and adrenals.
Results:
Histologically, there was no evidence of COVID-19-specific changes in the pituitary and adrenal glands. Large pituitary necrosis may be interpreted as a shock reaction. Independent of infection, we found one T-cell lymphoma, two adenomas, and four Rathke-type cysts in the pituitary glands, and 70% of the adrenal glands showed decreased lipid content and an increase in compact cells as a stress response. In addition, a cortical adenoma in one adrenal gland and small cortical nodules in three adrenal glands were detected independently of COVID-19.
Conclusion:
Pituitary and adrenal glands do not appear histologically predominant in the course of COVID-19.
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