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Related Experiment Video

Updated: Sep 29, 2025

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Published on: June 23, 2022

High-Resolution Separation of Nanoparticles Using a Negative Magnetophoretic Microfluidic System.

Lin Zeng¹, Xi Chen¹, Rongrong Zhang¹

¹Laboratory of Biomedical Microsystems and Nano Devices, Bionic Sensing and Intelligence Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

|March 26, 2022

Summary

A novel microfluidic system utilizing negative magnetophoresis achieves high-purity separation of nanoparticles. This advanced system effectively isolates nano-sized particles, offering improved resolution and throughput for analytical applications.

Keywords:

microfluidic chip nanoparticles negative magnetophoresis separation

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Last Updated: Sep 29, 2025

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Published on: November 23, 2015

Area of Science:

Nanotechnology
Microfluidics
Biophysics

Background:

Effective separation of nano-sized particles is crucial for analysis but current methods lack resolution.
Existing techniques struggle with purifying nanoparticles from complex sample media.

Purpose of the Study:

To develop a high-resolution microfluidic system for nanoparticle separation.
To enhance purification efficiency and sample processing throughput using negative magnetophoresis.

Main Methods:

A microfluidic system with on-chip magnetic pole arrays and permalloys was designed.
Four permanent magnets generated strong magnetic fields, creating a high magnetic field gradient (10,000 T/m).
Negative magnetophoresis was employed to separate particles based on size.

Main Results:

High-purity separation of 200 nm particles from a mixture (1000 nm and 200 nm) was achieved.
Overall particle recovery reached 99%, with 84.2% for 200 nm particles and 98.2% purity.
The system demonstrated high resolution (800 nm size difference) and improved throughput (2.5 μL/min).

Conclusions:

The developed microfluidic system offers a novel solution for high-purity nanoparticle separation.
This technology is promising for applications in nanobiological sample purification and analysis.
The system surpasses existing negative magnetophoretic methods in resolution and throughput.