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Related Experiment Video

Updated: Sep 29, 2025

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
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Multivalent Aptamer Approach: Designs, Strategies, and Applications.

Zhong Wang1, Xiuying Yang2, Nicholas Zhou Lee3

  • 1Ottawa-Carleton Institute of Biomedical Engineering, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Micromachines
|March 26, 2022
PubMed
Summary

Multivalent aptamers, combining multiple aptamers, offer enhanced binding affinity and stability. This review highlights their structures, design, and recent advances in biosensing and biomedical applications.

Keywords:
antibodiesaptamersaviditybiosensorsdetectionmultivalence

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Biochemistry

Background:

  • Aptamers are single-stranded DNA or RNA molecules with specific target-binding capabilities.
  • Multivalent aptamers are constructs combining two or more aptamers, enhancing avidity and stability.
  • Increased avidity leads to higher binding affinities compared to single aptamer units.

Purpose of the Study:

  • To review recent advancements in multivalent aptamer research.
  • To discuss the structural characteristics and design strategies of multivalent aptamers.
  • To highlight the applications of multivalent aptamers in biosensing and medicine.

Main Methods:

  • Literature review of recent developments in multivalent aptamer technology.
  • Analysis of structural diversity and design principles for multivalent aptamers.
  • Examination of case studies showcasing applications in biosensing and biomedical fields.

Main Results:

  • Multivalent aptamers exhibit superior binding affinity and stability over monomeric aptamers.
  • Diverse structural designs enable tailored multivalent aptamer functionalities.
  • Significant progress has been made in applying multivalent aptamers to sensitive biosensing and therapeutic strategies.

Conclusions:

  • Multivalent aptamer technology presents a promising platform for advanced diagnostics and therapeutics.
  • Further research into design and application will expand their clinical utility.
  • The enhanced properties of multivalent aptamers are key to their growing importance in biotechnology.