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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...

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High Throughput Single-cell and Multiple-cell Micro-encapsulation
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Encapsulation of Orange Oil Using Fluidized Bed Granulation.

Gary Reineccius1, Shardul Patil1, Vaidhyanathan Anantharamkrishnan1

  • 1Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55018, USA.

Molecules (Basel, Switzerland)
|March 26, 2022
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Summary

Fluidized bed granulation (FBG) offers superior results for creating dense, stable flavoring particles compared to spray drying (SD) or spray drying followed by agglomeration (SD/Agg). FBG enhances orange oil retention and oxidative stability in dry flavorings.

Keywords:
agglomerationencapsulationflavorspray drying

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Area of Science:

  • Food Science and Technology
  • Particle Engineering
  • Encapsulation Technologies

Background:

  • Dry flavoring powders often require processing for improved handling and stability.
  • Traditional methods like spray drying (SD) and agglomeration (Agg) can be multi-step and may not yield optimal particle properties.
  • Fluidized bed granulation (FBG) presents a potential alternative for producing enhanced flavoring particles.

Purpose of the Study:

  • To compare fluidized bed granulation (FBG) against spray drying (SD) and spray drying followed by agglomeration (SD/Agg) for producing flavoring particles.
  • To evaluate particle size, density, oil retention, and oxidative stability of encapsulated orange peel oil using different methods.

Main Methods:

  • Preparation of a 55% solids slurry using OSAn-modified starch and maltodextrin 15DE.
  • Addition of single-fold orange peel oil at 20% (for SD) and 25% (for FBG) of carrier solids.
  • Processing via spray drying (SD), subsequent agglomeration (Agg), and fluidized bed granulation (FBG).

Main Results:

  • Fluidized bed granulation (FBG) produced flavoring particles with higher density compared to SD or SD/Agg powders.
  • FBG resulted in superior orange oil retention and enhanced oxidative stability during storage.
  • The FBG process yielded encapsulates with improved overall properties for dry flavorings.

Conclusions:

  • Fluidized bed granulation (FBG) is an effective single-step method for producing high-quality encapsulated flavorings.
  • FBG offers advantages over spray drying and agglomeration in terms of particle density, oil retention, and oxidative stability.
  • This method negates the need for a two-step process, simplifying the production of improved dry flavoring powders.