LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection

Area of Science:

• Mycology
• Immunology
• Molecular Biology

Background:

• Candidiasis presents global health challenges due to rising incidence, recurrence, and drug-resistant strains.
• Existing antifungal treatments face limitations, necessitating novel therapeutic approaches.
• Host-directed therapies (HDTs) are emerging as effective adjuncts to standard antifungal regimens.

Purpose of the Study:

• To review recent advances in HDTs for Candida infections, focusing on Candida-host interactions.
• To highlight the role and application strategies of long noncoding RNAs (lncRNAs) in modulating host immune responses.
• To explore the potential of targeting lncRNAs as a novel HDT strategy for candidiasis.

Main Methods:

• Literature review of recent studies on Candida-host interactions and HDTs.
• Emphasis on research detailing the involvement of lncRNAs in the host immune response to Candida.
• Analysis of findings related to lncRNA expression patterns and their functional impact.

Main Results:

• HDTs demonstrate efficacy as adjuncts to conventional antifungal therapies.
• lncRNAs exhibit specific expression patterns and influence biological processes, including immune responses.
• Targeting lncRNAs presents a feasible strategy to modulate host defense mechanisms against Candida.

Conclusions:

• lncRNAs hold significant potential as specific molecular targets for developing novel HDTs.
• Modulating host defense through lncRNAs offers a new perspective for candidiasis treatment.
• Further research into lncRNA-based HDTs could overcome limitations of current antifungal strategies.