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Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
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Finite Element Analysis and Modeling in Pharmaceutical Tableting.
Ioannis Partheniadis1, Vasiliki Terzi2, Ioannis Nikolakakis1
1Department of Pharmaceutical Technology, Faculty of Health Sciences, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Pharmaceutics
|March 26, 2022
Summary
Finite element analysis (FEA) offers powerful computational solutions for pharmaceutical powder compression. This review explores FEA
Area of Science:
- Pharmaceutical Sciences
- Computational Mechanics
- Materials Science
Background:
- Pharmaceutical powder compression involves complex physical phenomena.
- Finite element analysis (FEA) has been used since the early 2000s to model these phenomena.
- Understanding powder compression is crucial for effective tablet manufacturing.
Purpose of the Study:
- To review the potential and feasibility of FEA in pharmaceutical tableting.
- To elucidate key aspects of powder compression using FEA.
- To present constitutive models and theoretical backgrounds for tablet compression and fracture.
Main Methods:
- Review of existing literature on FEA applications in pharmaceutical tableting.
- Discussion of constitutive material models relevant to powder compression.
- Analysis of FEA for predicting stress, density, temperature, friction, and failure.
Main Results:
- FEA provides numerical solutions for complex powder compression mechanisms.
- FEA can elucidate stress/density distributions, temperature evolution, and friction effects.
- FEA aids in understanding tablet formation, punch shape influence, and fracture under stress.
Conclusions:
- FEA is a feasible and valuable tool for pharmaceutical tableting research.
- FEA applications demonstrate its utility and highlight future potential in tablet design and manufacturing.
- Further research can leverage FEA for optimizing tablet properties and predicting performance.
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