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Acute generalized exanthematous pustular dermatitis and viral infection
Dermatologica
|January 1, 1986
Summary
Acute generalized exanthematous pustular dermatitis (AGEPD) is a distinct clinical entity. This viral-associated rash, potentially linked to psoriasis predisposition, requires early diagnosis to avoid aggressive treatments.
Area of Science:
- Dermatology
- Virology
- Pathology
Background:
- Acute generalized exanthematous pustular dermatitis (AGEPD) is a newly identified clinical condition.
- It presents with a characteristic rash, fever, and specific histological findings.
Observation:
- Three patients with AGEPD exhibited generalized erythema, erythema multiforme, and amicrobial pustules.
- Symptoms included fever and spontaneous healing within 10 days.
- Pharyngitis preceded the rash by one week in all patients.
Findings:
- Histological examination revealed a mixed neutrophilic and eosinophilic vasculitis and eosinophilic pustules.
- Two patients had high-titered IgM antibodies to enteroviruses.
- One patient had enterovirus detected in stool and urine samples.
Implications:
- AGEPD is likely associated with enteroviral infections.
- A genetic predisposition to psoriasis may play a role in susceptibility.
- Early diagnosis is crucial to differentiate AGEPD from pustular psoriasis and prevent inappropriate aggressive therapies.