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New Drugs Update: Finerenone, Difelikefalin, and Avacopan
1Harding University, Searcy Arkansas.
The Senior Care Pharmacist
|March 26, 2022
Summary
This article reviews three drugs: finerenone for chronic kidney disease in type 2 diabetes, difelikefalin for kidney disease-related itching, and avacopan for ANCA-associated vasculitis. These medications offer new therapeutic options for specific patient populations.
Area of Science:
- Nephrology
- Cardiology
- Rheumatology
Background:
- Chronic kidney disease (CKD) and its complications pose significant health burdens.
- Type 2 diabetes (T2D) is a major risk factor for CKD.
- ANCA-associated vasculitis (AAV) is a serious autoimmune condition requiring effective treatment.
Purpose of the Study:
- To review the indications and therapeutic applications of finerenone, difelikefalin, and avacopan.
- To highlight the role of these novel agents in managing specific kidney diseases, cardiovascular risks, and autoimmune conditions.
Main Methods:
- Review of FDA-indicated uses for finerenone (Kerendia™), difelikefalin (Korsuva™), and avacopan (Tavneos™).
- Discussion of patient populations and conditions targeted by each drug.
Main Results:
- Finerenone is indicated to reduce risks associated with CKD in T2D, including eGFR decline and cardiovascular events.
- Difelikefalin is approved for treating moderate-to-severe pruritus in hemodialysis patients with CKD.
- Avacopan serves as an adjunctive therapy for severe active AAV (GPA and MPA) alongside standard treatments.
Conclusions:
- Finerenone, difelikefalin, and avacopan represent important advancements in treating specific conditions related to kidney disease and autoimmune disorders.
- These drugs offer targeted therapeutic benefits for patients with CKD, T2D, pruritus, and AAV.
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