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[Toxoplasmosis after bone marrow transplantation].

D W Beelen, H K Mahmoud, M L Mlynek

    Immunitat Und Infektion
    |September 1, 1986
    PubMed
    Summary

    Toxoplasma gondii opportunistic infections are rare but serious complications after bone marrow transplantation. Early diagnosis of toxoplasmosis is challenging due to varied symptoms and antibody titer interpretation issues.

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    Area of Science:

    • Immunology
    • Infectious Diseases
    • Hematology

    Background:

    • Bone marrow transplantation (BMT) can lead to immunocompromised states, increasing susceptibility to opportunistic infections.
    • Toxoplasma gondii is an opportunistic pathogen that can cause severe disease in immunocompromised individuals.

    Observation:

    • This report details 3 cases of manifest toxoplasmosis among 86 bone marrow transplant recipients.
    • The infection primarily affected the central nervous system and cardiac muscle, presenting as acute disseminated encephalitis and myocarditis.

    Findings:

    • Diagnosing toxoplasmosis in BMT patients is difficult due to variable clinical presentations and challenges in interpreting antibody titers.
    • In these 3 cases, the diagnosis of toxoplasmosis was only confirmed post-mortem.

    Implications:

    • Highlights the critical need for improved diagnostic strategies for toxoplasmosis in immunocompromised BMT patients.
    • Underscores the potential severity and diagnostic challenges of Toxoplasma gondii reactivation post-transplantation.

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