Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

24.4K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
24.4K
Replication in Eukaryotes01:29

Replication in Eukaryotes

14.9K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
14.9K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.8K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.8K
Vitamins01:30

Vitamins

1.0K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
1.0K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.8K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.8K
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

4.6K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Association of micronutrient levels with dementia risk in adults in Telangana, India: a cross-sectional study (2023-2024)" [The Lancet Regional Health-Southeast Asia Volume 50, July 2026, 100794].

The Lancet regional health. Southeast Asia·2026
Same author

Association of micronutrient levels with dementia risk in adults in Telangana, India: a cross-sectional study (2023-2024).

The Lancet regional health. Southeast Asia·2026
Same author

Ultra-Processed Food Consumption Patterns and Their Association with Blood Pressure Among Young Adults: A Cross-Sectional Study.

Nutrients·2026
Same author

Prevention of diabetic retinopathy in a rat model by a functional food mix.

Molecular vision·2026
Same author

Impact of Maternal Riboflavin Deficiency on the Growth and Development of Offspring Rats.

Birth defects research·2026
Same author

Evaluating the prebiotic potential of a glucan EPS from Enterococcus hirae OL616073: Digestive resistance, probiotic growth stimulation, and gut microbiome modulation.

Food research international (Ottawa, Ont.)·2025

Related Experiment Video

Updated: Sep 29, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.7K

Telomere length and vitamin B12.

Guruvaiah Praveen1, Mudili Sivaprasad1, G Bhanuprakash Reddy1

  • 1Department of Biochemistry, ICMR-National Institute of Nutrition, Hyderabad, India.

Vitamins and Hormones
|March 26, 2022
PubMed
Summary

Vitamin B12 (B12) influences telomere length (TL), a marker of biological aging. B12 deficiency elevates homocysteine and oxidative stress, compromising TL and cellular aging, while adequate B12 supports telomere integrity.

Keywords:
8-Oxo-GAgingHomocysteineMethylationMitochondrial DNA copy number oxidative stressTelomeraseTelomere lengthVitamin B12

More Related Videos

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

2.2K
Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

3.2K

Related Experiment Videos

Last Updated: Sep 29, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.7K
Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

2.2K
Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

3.2K

Area of Science:

  • Genetics
  • Molecular Biology
  • Aging Research

Background:

  • Telomeres protect chromosome ends and shorten with cell division, correlating with biological aging.
  • Telomere attrition is linked to mortality and age-related diseases.
  • Micronutrients, including vitamin B12, may modulate oxidative stress and influence telomere length.

Purpose of the Study:

  • To explore the role of vitamin B12 in influencing telomere length (TL).
  • To understand the connection between vitamin B12, oxidative stress, and cellular aging.
  • To investigate the link between vitamin B12, telomere length, and mitochondrial biogenesis.

Main Methods:

  • Review of existing research on telomeres, vitamin B12, oxidative stress, and aging.
  • Analysis of studies linking vitamin B12 deficiency to elevated homocysteine and oxidative stress.
  • Examination of evidence associating vitamin B12 with relative telomere length and mitochondrial DNA copy number.

Main Results:

  • Vitamin B12 deficiency increases homocysteine, reduces methylation potential, and elevates oxidative stress, negatively impacting telomere length.
  • Vitamin B12 positively influences telomere integrity and cellular aging.
  • Vitamin B12 is associated with relative telomere length and mitochondrial DNA copy number, suggesting a role in mitochondrial biogenesis.

Conclusions:

  • Vitamin B12 plays a crucial role in maintaining telomere integrity and influencing biological aging.
  • Understanding the vitamin B12-telomere length association may offer new insights into aging pathophysiology.
  • Further research into this association could reveal novel therapeutic strategies for age-related diseases.