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Updated: Sep 29, 2025

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
Published on: January 17, 2020
GIS based interpolation method to urinary metal concentrations in Malaysia
Noraishah Mohammad Sham1, Zurahanim Fasha Anual1, Rafiza Shaharudin1
1Environmental Health Research Centre, Institute for Medical Research, Ministry of Health Malaysia, 40170, Shah Alam, Selangor, Malaysia.
Heavy metal contamination, including arsenic, cadmium, nickel, and lead, is a growing public health concern. This study mapped their distribution in Malaysian adults, revealing regional hotspots for exposure.
Area of Science:
- Environmental Health
- Toxicology
- Public Health
Background:
- Environmental contamination by heavy metals like arsenic (As), cadmium (Cd), nickel (Ni), and lead (Pb) poses significant ecological and global public health risks.
- Understanding the spatial distribution of these toxic elements in human populations is crucial for targeted interventions.
Purpose of the Study:
- To visualize the geographical distribution of arsenic, cadmium, nickel, and lead concentrations in the urine of Malaysian adults.
- To identify regions with higher heavy metal exposure levels within Malaysia.
Main Methods:
- A cross-sectional study involving 817 Malaysian adults, with urine samples collected between October 2017 and March 2018.
- Spatial Inverse Distance Weighted (IDW) interpolation was employed to map metal concentrations.
- Moran's I Index was utilized to assess spatial autocorrelation of heavy metals.
Main Results:
- Highest mean concentrations of nickel (Ni) and cadmium (Cd) were observed in Perak.
- Arsenic (As) and lead (Pb) were predominantly found in the East Coast region (Terengganu and Kelantan).
- Significant spatial autocorrelation was detected for As, Cd, and Ni, but not for Pb.
- IDW mapping indicated elevated As and Cd levels in the North East and Western regions, with lower exposure in Central compared to North regions.
Conclusions:
- Geospatial analysis effectively visualizes heavy metal exposure patterns in a population.
- Identifying regional hotspots for specific heavy metals aids health authorities in predicting exposure and prioritizing control measures.
- The findings highlight the need for targeted public health strategies to mitigate heavy metal exposure in Malaysia.
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