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Smart nanocomposite assemblies for multimodal cancer theranostics
1Department of Pharmaceutical Chemistry & Quality Assurance, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.
Abstract:
Despite great strides in anticancer research, performance statistics of current treatment modalities remain dismal, highlighting the need for safe, efficacious strategies for tumour mitigation. Non-invasive fusion technology platforms combining photodynamic, photothermal and hyperthermia therapies have emerged as alternate strategies with potential to meet many of the unmet clinical demands in the domain of cancer. These therapies make use of metallic and magnetic nanoparticles with light absorbing properties, which are manipulated to generate either reactive cytotoxic oxygen species or heat for tumour ablation. Combination therapies integrating light, heat and magnetism-mediated nanoplatforms with the conventional approaches of chemotherapy, radiotherapy and surgery are emerging as precision medicine for targeted interventions against cancer. This article aims to compile recent developments of advanced nanocomposite assemblies that integrate multimodal therapeutics for cancer treatment. Amalgamation of various effective, non-invasive technological platforms such as photodynamic therapy (PDT), photothermal therapy (PTT), magnetic hyperthermia (MHT), and chemodynamic therapy (CDT) have tremendous potential in presenting safe and efficacious solutions to the formidable challenges in cancer therapeutics.
Insights
Advanced nanocomposite assemblies offer safe and effective cancer treatment by combining photodynamic, photothermal, and magnetic hyperthermia therapies. These non-invasive strategies show promise for targeted tumor ablation and improved therapeutic outcomes.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Current cancer treatments have limited efficacy, necessitating novel therapeutic strategies.
- Non-invasive fusion technologies offer promising alternatives for tumor mitigation.
- Metallic and magnetic nanoparticles are key components in advanced cancer therapies.
Purpose of the Study:
- To compile recent developments in advanced nanocomposite assemblies for multimodal cancer treatment.
- To highlight the integration of various non-invasive therapeutic platforms.
- To explore the potential of these strategies in precision medicine.
Main Methods:
- Utilizing metallic and magnetic nanoparticles with light-absorbing properties.
- Combining photodynamic therapy (PDT), photothermal therapy (PTT), and magnetic hyperthermia (MHT).
- Integrating these nanoplatforms with conventional treatments like chemotherapy and radiotherapy.
Main Results:
- Nanocomposite assemblies enable the generation of reactive oxygen species or heat for tumor ablation.
- Multimodal therapies offer targeted interventions against cancer.
- These integrated approaches demonstrate potential for safe and efficacious cancer treatment.
Conclusions:
- Advanced nanocomposite assemblies represent a significant advancement in cancer therapeutics.
- The integration of PDT, PTT, MHT, and chemodynamic therapy (CDT) provides potent solutions.
- These non-invasive strategies hold great promise for addressing challenges in cancer treatment.
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