Related Experiment Video
Updated: Sep 29, 2025
04:38
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
10.4K
Symptomatic plaque enhancement is associated with early-onset post-stroke depression
Fan Liu1, Mingyu Song1, Xia Huang2
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Journal of Affective Disorders
|March 26, 2022
Summary
The enhancement index of symptomatic plaques is a key imaging marker for predicting early-onset post-stroke depression (PSD). This finding aids in the early diagnosis of PSD in stroke patients.
Area of Science:
- Neurology
- Radiology
- Psychiatry
Background:
- The relationship between imaging characteristics of intracranial atherosclerotic plaques and early-onset post-stroke depression (PSD) remains unclear.
- Investigating imaging biomarkers for PSD is crucial for timely intervention.
Purpose of the Study:
- To determine if imaging features of symptomatic intracranial atherosclerotic plaques predict early-onset PSD.
- To identify independent predictors of early-onset PSD in ischemic stroke patients.
Main Methods:
- 76 ischemic stroke patients underwent high-resolution vessel wall MRI (HR-VWI).
- Patients were classified into PSD and non-PSD groups based on DSM-V criteria and HAMD-17 scores at 14 days post-stroke.
- Analysis included comparison of clinical data, plaque imaging features (enhancement index, remodeling index, plaque surface irregularity), and logistic regression to identify predictors.
Main Results:
- 36 patients had early-onset PSD.
- Symptomatic plaque enhancement index (EI) and infarct volume were significantly higher in the PSD group (P < 0.05).
- Symptomatic plaque EI was an independent predictor of early-onset PSD (OR = 1.034, P = 0.001), even after adjusting for infarct volume. EI, infarct volume, and HAMD-17 scores were positively correlated.
Conclusions:
- The enhancement index of symptomatic plaques is a significant independent imaging biomarker for early-onset PSD.
- This imaging marker can assist in the early diagnosis of post-stroke depression.
Related Concept Videos
01:30Atherosclerosis I: Introduction
137
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
137
01:25Endocarditis II: Clinical Features of Infective Endocarditis
35
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
35
01:26Alzheimer's Disease: Overview
705
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
705
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
64
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
64
01:26Coronary Artery Disease II: Pathophysiology
62
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
62
01:30Coronary Artery Disease III: Clinical Manifestations
51
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
51