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Updated: Sep 29, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

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Delivery of mRNA for regulating functions of immune cells

Jia Shi1, Meng-Wen Huang1, Zi-Dong Lu2

  • 1School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 511442, PR China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 26, 2022
PubMed

Insights

Messenger RNA (mRNA) therapy shows promise for treating diseases by regulating immune cells. Effective delivery systems, like lipid nanoparticles (LNPs), are crucial for advancing this therapeutic approach.

Area of Science:

  • Immunology
  • Biotechnology
  • Therapeutics

Background:

  • Abnormal immune cell function is linked to cancer, autoimmune diseases, and infections.
  • Messenger RNA (mRNA)-based therapies offer a way to modulate immune cell functions for therapeutic benefit.
  • Challenges in mRNA therapy include its instability and inefficient cellular entry.

Purpose of the Study:

  • To review the barriers hindering mRNA delivery into immune cells.
  • To highlight advancements in mRNA delivery systems for immune cell regulation.
  • To explore the potential of mRNA therapy targeting various immune cells beyond dendritic cells (DCs).

Main Methods:

  • Literature review of mRNA delivery systems and their application in immune cell therapy.
  • Analysis of challenges associated with mRNA stability and cellular uptake.
  • Examination of lipid nanoparticle (LNP) technology as a successful mRNA delivery vehicle.

Main Results:

  • Lipid nanoparticles (LNPs) have proven effective in delivering mRNA to dendritic cells (DCs), as demonstrated by COVID-19 vaccines.
  • Various immune cells are identified as potential targets for mRNA-based therapies.
  • Significant progress has been made in overcoming delivery barriers for mRNA therapeutics.

Conclusions:

  • Effective mRNA delivery systems are essential for the success of mRNA-based immunotherapies.
  • Targeting diverse immune cells with mRNA offers broad therapeutic potential for various diseases.
  • Continued advancements in delivery technologies will accelerate the development of mRNA therapies.
Keywords:
Drug deliveryImmune cellsImmunotherapyVaccinemRNA

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