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Cellular senescence and acute kidney injury
Xiaoxi Lin1, Heng Jin2, Yanfen Chai1
1Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, China.
Pediatric Nephrology (Berlin, Germany)
|March 26, 2022
Summary
Cellular senescence plays a critical role in acute kidney injury (AKI) progression to chronic kidney disease (CKD). Targeting senescence pathways, including the senescence-associated secretory phenotype (SASP), offers a promising strategy to improve AKI prognosis and prevent CKD.
Area of Science:
- Nephrology
- Cellular Biology
- Pathology
Background:
- Acute kidney injury (AKI) is a common complication of serious illness, often leading to chronic kidney disease (CKD).
- Cellular senescence, characterized by irreversible cell cycle arrest and altered cellular functions, is observed early in AKI.
- Senescence is a critical factor influencing AKI prognosis and progression to CKD.
Purpose of the Study:
- To review the role of cellular senescence in AKI.
- To explore the mechanisms linking AKI to CKD via senescence, including the senescence-associated secretory phenotype (SASP).
- To identify research directions for improving AKI outcomes and preventing CKD progression.
Main Methods:
- Literature review of existing animal studies and research on cellular senescence in AKI.
- Analysis of the role of SASP and senescence-related pathways in AKI and CKD.
- Integration of findings to propose therapeutic strategies targeting senescence.
Main Results:
- Cellular senescence is an early event in AKI and is critical for prognosis.
- Acute senescence has an active role, while chronic senescence dominates AKI to CKD progression.
- SASP and related pathways amplify senescence signals, contributing to disease progression.
Conclusions:
- Senescence is a key driver in the transition from AKI to CKD.
- Targeting senescence, particularly through reprogramming strategies, holds potential for blocking CKD progression.
- Further research into senescence mechanisms is crucial for developing effective interventions for AKI and CKD.
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