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Published on: June 15, 2018
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Noncoding RNAs in age-related cardiovascular diseases
Amela Jusic1, Pınar Buket Thomas2, Stephanie Bezzina Wettinger3
1Cardiovascular Research Unit, Luxembourg Institute of Health, Strassen, Luxembourg.
Ageing Research Reviews
|March 26, 2022
Summary
Noncoding RNAs (ncRNAs) regulate aging processes that increase cardiovascular disease (CVD) risk. This review explores ncRNAs
Area of Science:
- Biomedical science
- Molecular biology
- Cardiovascular research
Background:
- Cardiovascular diseases (CVDs) are a major global health issue, causing significant mortality and economic burden.
- Aging is a primary risk factor for CVDs, involving complex biological processes.
- Noncoding RNAs (ncRNAs), which do not code for proteins, are increasingly recognized for their regulatory roles in biological processes, including aging.
Purpose of the Study:
- To review the critical roles of ncRNAs in the biological processes of aging.
- To examine the involvement of ncRNAs in cardiovascular pathophysiology.
- To discuss the therapeutic potential of ncRNAs for treating CVDs.
Main Methods:
- Literature review of scientific articles on ncRNAs, aging, and cardiovascular diseases.
- Synthesis of current knowledge on ncRNA regulation of aging-related pathways (e.g., oxidative stress, mitochondrial dysfunction, inflammation).
- Analysis of ncRNA involvement in cardiovascular conditions such as arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction, and heart failure.
Main Results:
- ncRNAs are key regulators of cellular aging mechanisms that contribute to cardiovascular risk.
- Dysregulation of specific ncRNAs is implicated in the development and progression of various cardiovascular diseases.
- ncRNAs influence multiple pathways central to cardiovascular aging and disease pathogenesis.
Conclusions:
- ncRNAs play significant roles in both cardiovascular aging and the development of cardiovascular diseases.
- Targeting ncRNAs presents a promising therapeutic strategy for managing cardiovascular aging and disease.
- Further research into ncRNA mechanisms and therapeutic applications is warranted for CVDs.
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