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Updated: Sep 29, 2025

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

8.1K

Mini-review: Antibody-PET of receptor tyrosine kinase interplay and heterogeneity

Anusha Chegu1, Sandeep Surendra Panikar2, Patricia M R Pereira2

  • 1Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States of America; Department of Biology, Washington University School of Medicine, St. Louis, MO 63130-4899, United States of America.

Nuclear Medicine and Biology
|March 26, 2022
PubMed

Insights

Receptor tyrosine kinase (RTK)-targeted therapies are limited by tumor resistance. RTK-targeted PET imaging offers real-time, whole-body insights into RTK heterogeneity and co-activation, aiding cancer management and recurrence detection.

Area of Science:

  • Oncology
  • Radiochemistry
  • Molecular Imaging

Background:

  • Targeted therapies for receptor tyrosine kinases (RTKs) show variable efficacy due to tumor heterogeneity and co-activation.
  • Non-invasive positron emission tomography (PET) combined with RTK-specific antibodies allows real-time, in-vivo study of cancer biology.
  • RTK-targeted antibody-PET imaging conjugates are emerging tools for oncology patient management.

Purpose of the Study:

  • To review clinical and preclinical data on RTK-targeted PET imaging.
  • To focus on detecting RTK heterogeneity and co-activation as mechanisms of tumor resistance.
  • To provide an overview of recent RTK-targeted PET imaging studies.

Main Methods:

  • Review of clinical and preclinical studies published within the last 4 years.
  • Focus on studies utilizing RTK-specific antibody-PET imaging conjugates.
  • Analysis of data related to RTK heterogeneity and co-activation in tumors.

Main Results:

  • RTK-targeted PET imaging can visualize RTK heterogeneity and co-activation in real-time.
  • This imaging modality shows potential for early cancer diagnosis and treatment response assessment.
  • Studies demonstrate the utility of RTK-targeted PET in understanding tumor resistance mechanisms.

Conclusions:

  • RTK-targeted PET imaging is a valuable tool for assessing tumor resistance mechanisms like RTK heterogeneity and co-activation.
  • This technique aids in prognostic information and imaging disease recurrence.
  • RTK-targeted antibody-PET conjugates hold significant promise for personalized oncology.
Keywords:
AntibodyCo-activationHeterogeneityPET/CTRTK

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