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Nitric oxide delivery platforms derived from a photoactivatable Mn(II) nitrosyl complex: Entry to photopharmacology
1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Abstract:
The manganese nitrosyl complex derived from a designed pentadentate ligand with one carboxamido group N,N-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-carboxamide (PaPy3H; H is the dissociable carboxamide H), namely, [Mn(PaPy3)(NO)]ClO4 (1), serves as an excellent biocompatible source of nitric oxide (NO) when exposed to low power (10-100 mW/cm2) visible light. This complex has afforded a series of NO delivery platforms that could find applications in combating chronic infections by drug-resistant bacteria under the control of light.
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