Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: A method for supervoxel-wise association studies of age and other non-imaging variables from coronary computed tomography angiograms.

Scientific reports·2026
Same author

A method for tissue-mask supported whole-body image registration in the UK Biobank.

Scientific reports·2026
Same author

A parameterized gamma-variate function can describe the temporal response of cerebral blood flow after Acetazolamide injection in Moyamoya patients.

Neuroimage. Reports·2026
Same author

Characterization of a distinct form of vimentin in the neurodegenerative brain.

Acta neuropathologica communications·2026
Same author

Time-Driven Survival Analysis from FDG-PET/CT in Non-Small Cell Lung Cancer.

Annals of biomedical engineering·2026
Same author

Safety, tolerability, and efficacy of acetazolamide in idiopathic normal pressure hydrocephalus (DRAIN) in Sweden: a randomised, double-blind, placebo-controlled, phase 2 trial.

The Lancet. Neurology·2026
Same journal

Proton RBE for in vivo model systems: LET and dose dependencies for early and late biological endpoints.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same journal

AI-augmented thyroid scintigraphy for robust classification of disease.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same journal

Updating national diagnostic reference levels for adult cardiac interventional procedures in Switzerland.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same journal

Adoption of AI-driven automation and adaptive radiotherapy in clinical practice: results from a national survey.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same journal

Sivan Unit (SU) for standardization of voxel intensity in CBCT: A multi-vendor, multi-centric validation study.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same journal

VIT-MBRT, a GPU accelerated Monte Carlo tool for investigations on preclinical minibeam radiation therapy.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
See all related articles

Related Experiment Video

Updated: Sep 28, 2025

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

409

Composite attenuation correction method using a 68Ge-transmission multi-atlas for quantitative brain PET/MR.

João M Sousa1, Lieuwe Appel2, Mathias Engström3

  • 1Radiology & Molecular Imaging, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|March 27, 2022
PubMed
Summary
This summary is machine-generated.

A new composite transmission (CTR-AC) method for positron emission tomography/magnetic resonance (PET/MR) imaging offers accurate attenuation correction. This experimental technique shows promise for quantitative PET imaging, comparable to existing gold standards.

Keywords:
(68)Ge-transmission scanAttenuation correctionHybrid imagingKinetic modellingPET/MRI[(11)C]PE2I

More Related Videos

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

7.1K
Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

14.8K

Related Experiment Videos

Last Updated: Sep 28, 2025

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

409
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

7.1K
Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

14.8K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiophysics

Background:

  • Positron Emission Tomography (PET) attenuation correction (AC) is crucial for quantitative imaging.
  • Current PET/MR systems lack the gold standard 68Ge-transmission scanning for AC.
  • Existing MR-based AC (MRAC) methods have limitations in accuracy and precision.

Purpose of the Study:

  • To evaluate a novel composite transmission (CTR-AC) method for PET/MR attenuation correction.
  • To assess the accuracy and precision of CTR-AC for quantitative PET parameters.
  • To compare CTR-AC performance against a patient-specific 68Ge-AC map.

Main Methods:

  • Developed CTR-AC using a database of 125 68Ge-transmission maps and T1-weighted (T1w) MR images.
  • Employed non-rigid image registration to align database T1w MR images and corresponding 68Ge-AC maps.
  • Reconstructed dynamic [11C]PE2I PET images using CTR-AC and compared quantitative parameters (SUV, R1, BPND) with a reference standard.

Main Results:

  • CTR-AC demonstrated high accuracy for whole-brain Standardized Uptake Values (SUV) (0.5 ± 3.5% bias) and relative delivery (R1) (-0.1 ± 3.2% bias).
  • Accurate quantification of non-displaceable binding potential (BPND) in the putamen was achieved (3.7 ± 8.1% bias).
  • SUV and R1 precision was modest, particularly in the anterior cortex (-1.1 ± 6.4% bias for R1).

Conclusions:

  • The experimental CTR-AC method provides accurate MRAC maps with continuous linear attenuation coefficients.
  • CTR-AC performance is comparable to the best MRAC methods for both SUV and quantitative kinetic modeling.
  • This novel approach shows potential for accurate quantitative PET/MR imaging in clinical settings.