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Related Experiment Videos

Disseminated cryptococcosis presenting as cellulitis with necrotizing vasculitis.

S K Shrader, J C Watts, J A Dancik

    Journal of Clinical Microbiology
    |November 1, 1986
    PubMed
    Summary

    Disseminated cryptococcosis rarely causes skin lesions, but this case highlights cellulitis and vasculitis in a renal transplant patient. Early diagnosis via skin biopsy led to successful treatment and preserved the kidney transplant.

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    Area of Science:

    • Medical Mycology
    • Transplant Infectious Diseases
    • Dermatopathology

    Background:

    • Disseminated cryptococcosis typically involves the central nervous system and lungs.
    • Cutaneous manifestations of cryptococcosis are uncommon and often present as polymorphous lesions.
    • Cellulitis and vasculitis are rare presentations of fungal infections, particularly Cryptococcus neoformans.

    Observation:

    • A renal transplant recipient presented with disseminated cryptococcosis manifesting as cellulitis and necrotizing vasculitis.
    • The skin lesions were indicative of a rare and aggressive form of cryptococcal infection.
    • Cryptococcal vascular invasion was suspected as the underlying cause of the vasculitis.

    Findings:

    • A diagnostic skin biopsy was crucial for identifying Cryptococcus neoformans in the context of cellulitis and vasculitis.

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  • Early initiation of antifungal therapy, guided by the biopsy results, led to a complete cure.
  • The prompt treatment successfully salvaged the patient's renal allograft, preventing graft loss.

    • Implications:

    • This case underscores the importance of considering atypical presentations of disseminated cryptococcosis, including skin involvement.
    • Diagnostic skin biopsies are vital for timely diagnosis and management of rare fungal infections in immunocompromised patients.
    • Successful treatment of cryptococcal cellulitis and vasculitis can prevent severe morbidity and preserve organ allografts in transplant recipients.