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Histone Methylation and Oxidative Stress in Cardiovascular Diseases

Xin Yi1,2,3, Qiu-Xia Zhu1,2,3, Xing-Liang Wu1,2,3

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Oxidative Medicine and Cellular Longevity
|March 28, 2022
PubMed

Insights

Oxidative stress and histone methylation are key in cardiovascular diseases. Understanding their interplay offers new therapeutic targets for conditions like atherosclerosis and hypertension.

Area of Science:

  • Cardiovascular Biology
  • Epigenetics
  • Oxidative Stress Research

Background:

  • Oxidative stress, caused by reactive oxygen species (ROS) overwhelming antioxidant defenses, is implicated in cardiovascular diseases.
  • Histone methylation is increasingly recognized as a regulator of oxidative stress.
  • The link between oxidative stress and histone methylation is critical for cardiovascular health and disease progression.

Purpose of the Study:

  • To review the interplay between histone methylation and oxidative stress in cardiovascular diseases.
  • To explore potential therapeutic strategies targeting this molecular mechanism.
  • To highlight the need for further research into bridging signaling pathways.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of studies on histone methylation and oxidative stress in cardiovascular contexts.
  • Examination of therapeutic implications of epigenetic modifications.

Main Results:

  • Histone methylation significantly influences oxidative stress levels in cardiovascular disease development.
  • Cardiovascular pathologies including atherosclerosis, coronary artery disease, pulmonary hypertension, and diabetic vascular complications are linked to this interplay.
  • Epigenetic modifiers show promise as therapeutic targets, similar to cancer treatments.

Conclusions:

  • Targeting the interplay between oxidative stress and histone methylation presents novel therapeutic avenues for cardiovascular disorders.
  • Further exploration of the comprehensive signaling pathways is essential for clinical translation.
  • This review consolidates current knowledge, guiding future research in cardiovascular epigenetics and oxidative stress.

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