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Selective androgen receptor modulators (SARMs) are popular supplements. A case report highlights their potential for liver injury (hepatotoxicity), emphasizing the need for clinical awareness.

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acute hepatotoxicityanabolic androgenic steroidandrogen receptorhepatotoxicityidiosyncratic drug reactionselective androgen receptor modulatorus fda

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Area of Science:

  • Pharmacology
  • Hepatology
  • Sports Medicine

Background:

  • Selective androgen receptor modulators (SARMs) are performance-enhancing supplements gaining popularity among athletes and bodybuilders.
  • Developed as alternatives to anabolic steroids, SARMs are purported to offer muscle and bone benefits with fewer androgenic effects.
  • Despite their availability, the U.S. Food and Drug Administration (FDA) has issued warnings regarding potential adverse health effects, including liver damage.

Observation:

  • A 29-year-old male presented with jaundice, fatigue, and abnormal liver function tests.
  • These symptoms emerged shortly after initiating SARM supplements.
  • The patient's condition showed improvement and eventual resolution upon discontinuation of the supplements.

Findings:

  • The case report documents a direct correlation between SARM supplement use and the onset of liver injury.
  • Elevated liver function tests and jaundice were key indicators of hepatotoxicity in this patient.
  • Cessation of SARM use led to the resolution of symptoms, suggesting a causal link.

Implications:

  • This case underscores the potential hepatotoxicity associated with SARM supplements.
  • Clinicians should be aware of SARMs as a potential cause of liver injury in athletes and bodybuilders.
  • Early identification and management of SARM-induced liver injury are crucial for patient recovery.