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Updated: Sep 28, 2025

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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Predictive Value of Combination of D-dimer and Fibrinogen in Diagnosing Acute CVST

Abhishek Pathak1,2, Varun Kumar Singh1,2, Anand Kumar1

  • 1Department of Neurology, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Annals of Neurosciences
|March 28, 2022
PubMed

Insights

The combination of D-dimer and fibrinogen tests can help in the early diagnosis of cerebral venous sinus thrombosis (CVST). This diagnostic approach offers higher specificity and positive predictive value for acute CVST.

Area of Science:

  • Neurology
  • Hematology
  • Diagnostic Medicine

Background:

  • Cerebral venous sinus thrombosis (CVST) is a rare stroke subtype.
  • Previous studies on D-dimer and fibrinogen for CVST diagnosis show varied results.

Purpose of the Study:

  • To investigate the utility of combined D-dimer and fibrinogen testing for early acute CVST diagnosis.

Main Methods:

  • Forty patients with confirmed acute CVST were enrolled.
  • D-dimer and fibrinogen levels were measured using a rapid latex agglutination assay.

Main Results:

  • The combined D-dimer and fibrinogen assay showed 75% sensitivity, 75% specificity, and 75% positive predictive value.
  • While sensitivity was lower than individual markers, specificity and PPV were improved.

Conclusions:

  • Combined D-dimer and fibrinogen testing may improve early diagnosis of acute CVST.
  • This approach could potentially enhance patient management strategies.
Abstract

Keywords:
CVSTD-dimerFibrinogenSensitivitySpecificity

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