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Updated: Aug 20, 2026
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Förster resonance energy transfer-based molecularly imprinted polymer /amine-functionalized metal-organic framework
Fatemeh Amiripour1, Shahram Ghasemi2, Seyed Naser Azizi1
1Analytical Division, Faculty of Chemistry, University of Mazandaran, Postal Code 47416-95447, Babolsar, Iran.
Abstract:
Herein, luminescent metal-organic framework (LMOF) is modified with molecularly imprinted polymer (MIP) and employed as an efficient and cost-effective nanoprobe for the determination of 4-nitrophenol (4-NP). Amine-UiO-66 support with unique luminescence property is chosen for creating the template of 4-NP using MIP to construct a highly selective LMOF-based sensor (amine-UiO-66/MIP nanocomposite). The imprinted sites formed at the surface of LMOF significantly enhance the selectivity of the probe for 4-NP over its analogs. 4-NP can effectively quench the fluorescent intensity of the optical sensor via the Förster resonance energy transfer (FRET) mechanism. Amine-UiO-66/MIP sensor provided the linear range of 0.05-50 μM and low limit of detection of 0.009 μM for sensing of 4-NP. The application of probe for the fluorometric analysis of real samples, including drinking and environmental water, provided satisfactory recovery results with low relative standard deviation (RSD).
