Jove
Visualize
Contact Us

Related Experiment Videos

Involucrin expression in vulvar lesions.

J M de Oliveira, V Saleiro

    The Journal of Reproductive Medicine
    |September 1, 1986
    PubMed
    Summary

    Involucrin, a key protein in skin, can serve as a diagnostic marker. Researchers observed its expression in various vulvar lesions, finding an unusual pattern specifically in lichen sclerosus.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Detection and quantification of hepatitis E virus in the absence of IgG and IgM anti-HEV in HIV-positive patients.

    Journal of applied microbiology·2018
    Same author

    Enteric viruses' dissemination in a private reserve of natural heritage.

    Letters in applied microbiology·2018
    Same author

    Hepatitis A virus infection in hepatitis C Brazilian patients.

    The Journal of infection·2003
    Same author

    Use of sephacryl high resolution (HR) in tetanus anatoxin purification.

    Bollettino chimico farmaceutico·2001
    Same author

    Differences in HCV antibody patterns in haemodialysis patients infected with the same virus isolate.

    Journal of medical virology·2001
    Same author

    Development and validation study for the chromatographic purification process for tetanus anatoxin on Sephacryl S-200 High Resolution.

    Bollettino chimico farmaceutico·1999
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Dermatology
    • Histopathology
    • Oncology

    Background:

    • Involucrin is a crucial precursor protein for the epidermal cornification process.
    • It forms the cornified envelope in the human stratum corneum.
    • Involucrin's role as a potential histologic marker in various skin conditions is under investigation.

    Purpose of the Study:

    • To investigate the expression patterns of involucrin in different types of vulvar lesions.
    • To determine if involucrin can serve as a reliable histologic marker for vulvar pathologies.
    • To identify any unique or unexpected patterns of involucrin expression in specific vulvar conditions.

    Main Methods:

    • Biopsy specimens from various vulvar lesions were collected.
    • Immunohistochemical staining techniques were employed to detect involucrin expression.
    • Staining patterns were analyzed and compared across different lesion types.

    Main Results:

    • Involucrin expression patterns generally aligned with previously described findings in similar integumentary pathologies.
    • A distinct and unexpected pattern of involucrin staining was observed in cases of vulvar lichen sclerosus.
    • This aberrant staining suggests a unique biological behavior of involucrin in this specific condition.

    Conclusions:

    • Involucrin demonstrates potential as a valuable histologic marker for analyzing vulvar lesions.
    • The observed unusual staining pattern in lichen sclerosus warrants further investigation into its pathogenetic significance.
    • Understanding these expression differences may aid in the diagnosis and classification of vulvar dermatoses.

    Related Experiment Videos