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Correlation between percentage of fat mass and level of disease activity in rheumatoid arthritis
Guadalupe Mendoza-Vázquez1,2, Francisco Espinoza-Gómez2, Alberto Daniel Rocha-Muñoz3
1Unidad de Investigación Epidemiologica y en Servicios de Salud y Unidad de Investigación Biomédica 02, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, OOAD Jalisco, Instituto Mexicano del Seguro Social, Guadalajara, México.
Introduction:
Controversies exist regarding the relationship between body fat and disease activity in patients with rheumatoid arthritis. The evaluation of the disease is critical for establishing treatment and prognosis. Fat mass could be a predictive factor for poor prognosis in rheumatoid arthritis because of its association with low- and high-grade inflammation.
Objective:
To evaluate the correlation between fat mass values and disease activity in patients with rheumatoid arthritis.
Materials And Methods:
This was a cross-sectional study. Eighty female patients diagnosed with rheumatoid arthritis (American College of Rheumatology of 1987) were evaluated. For each one, the evaluation determined fat mass using bioelectrical impedance analysis and disease activity using the Disease Activity Score on 28 joints (DAS28).
Results:
The mean age was 59.11 ± 9.92 years, with an average disease duration of 14.13 ± 10.13 years; 85% of patients showed a high body fat percentage. Pearson's correlation between DAS28 values and fat mass was r = 0.035 (p = 0.76).
Conclusion:
The levels of DAS28 showed no correlation with fat mass percentage. Further studies are required to clarify the factors that can modify these levels.
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