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Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
14:10

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination

Published on: July 3, 2007

Vivax and falciparum malaria seen at an Indian service hospital

V P Gopinathan, A R Subramanian

    The Journal of Tropical Medicine and Hygiene
    |April 1, 1986
    PubMed

    Insights

    This study analyzed malaria cases in Indian military personnel, finding Plasmodium falciparum most common. While most cases responded to treatment, a significant percentage showed chloroquine resistance, necessitating careful management.

    Area of Science:

    • Tropical Medicine
    • Infectious Diseases
    • Parasitology

    Background:

    • Malaria remains a significant public health concern, particularly in tropical regions.
    • Understanding the prevalence and drug resistance patterns of Plasmodium species is crucial for effective control strategies.
    • Military populations in endemic areas are at risk of malaria infection.

    Purpose of the Study:

    • To analyze the epidemiological characteristics and treatment outcomes of malaria cases in adult males managed in a military hospital.
    • To determine the prevalence of Plasmodium falciparum and Plasmodium vivax infections.
    • To assess the level of chloroquine resistance in malaria parasites.

    Main Methods:

    • Retrospective analysis of 740 adult male malaria cases managed between June 1978 and March 1981.
    • Identification of Plasmodium species through microscopy.
    • Evaluation of chloroquine sensitivity through an extended field test on 381 patients.

    Main Results:

    • Plasmodium falciparum was the predominant species (55.3%), followed by P. vivax (32.0%) and mixed infections (12.7%).
    • A significant proportion of patients (21.5%) exhibited variable chloroquine resistance.
    • Cerebral and haemopoietic involvement were the most common severe manifestations (12.4%).

    Conclusions:

    • Malaria management in this military cohort was primarily characterized by P. falciparum infections.
    • The emergence of chloroquine resistance poses a therapeutic challenge.
    • Timely recognition of atypical presentations and complications is essential for effective malaria treatment and supportive care.

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