Related Experiment Video

Updated: Sep 28, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.1K

Risk of ischaemic heart diseases and stroke in behçet disease: A systematic review and meta-analysis

Kai-Wen Chuang1, Hua-Ching Chang2,3,4

  • 1School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

European Journal of Clinical Investigation
|March 28, 2022
PubMed

Insights

Behçet disease (BD) is linked to a higher stroke risk but not ischaemic heart disease (IHD). This finding highlights the need for vigilance regarding vascular and neurological complications in BD patients.

Area of Science:

  • Rheumatology
  • Vascular Medicine
  • Neurology

Background:

  • Behçet disease (BD) is a systemic vasculitis characterized by mucocutaneous lesions.
  • The pathophysiology of vascular injury in BD suggests a correlation with cardiovascular diseases.
  • Previous research has not fully elucidated the specific associations between BD and ischaemic heart diseases (IHDs) or stroke.

Purpose of the Study:

  • To systematically investigate the association between Behçet disease and the risk of ischaemic heart diseases (IHDs).
  • To systematically investigate the association between Behçet disease and the risk of stroke.
  • To provide evidence-based insights for clinicians managing patients with BD.

Main Methods:

  • A comprehensive systematic literature search was conducted across major databases (PubMed, Embase, Web of Science, Cochrane Library) up to July 10, 2021.
  • Six observational studies (3 cohort, 2 cross-sectional, 1 mixed) involving 9,813 BD patients and 41,802 controls were included in the meta-analysis.
  • A random-effects model was employed for meta-analysis, with no language restrictions.

Main Results:

  • The meta-analysis revealed no statistically significant association between Behçet disease and ischaemic heart disease (IHD).
  • Patients with Behçet disease demonstrated a significantly elevated risk of stroke compared to healthy controls (aHR, 2.083; 95% CI, 1.339-3.240; p=0.001).
  • While some heterogeneity was observed, no significant publication bias was detected across the included meta-analyses.

Conclusions:

  • Behçet disease is significantly associated with an increased risk of stroke.
  • There is no significant association found between Behçet disease and ischaemic heart disease.
  • Clinicians should maintain a high index of suspicion for potential vascular and neurological complications in patients diagnosed with Behçet disease.
Abstract

Keywords:
Behçet diseasecerebrovascular accidentischaemic heart diseasesstroke

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.1K
A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

127

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.5K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
54
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
60
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
46
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
101
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
95