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A high-resolution dose calculation engine for X-ray microbeams radiation therapy.

Sarvenaz Keshmiri1, Sylvan Brocard1, Raphaël Serduc1,2

  • 1Université Grenoble-Alpes, UGA/INSERM UA7 STROBE, 2280 rue de la Piscine, Saint-Martin d'Hères, 38400, France.

Medical Physics
|March 28, 2022
PubMed
Summary

A new treatment planning system, penMRT, accurately calculates radiation doses for microbeam radiation therapy (MRT). This advancement enables precise dose mapping for complex treatments, improving patient care in radiosurgery.

Keywords:
Monte Carlo methoddose calculation enginemedium energy X-raysmicrobeam radiation therapymicrometric dose calculation gridssynchrotron radiation

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Area of Science:

  • Medical Physics
  • Radiotherapy
  • Computational Biology

Background:

  • Microbeam radiation therapy (MRT) utilizes synchrotron X-rays fractionated into microbeams for radiosurgery.
  • Promising preclinical results for brain tumors and epilepsy encourage clinical translation of MRT.

Purpose of the Study:

  • Develop a treatment planning system (TPS) for accurate MRT dose calculations in patients.
  • Address limitations of existing TPS in handling MRT's high-dose gradients and spatial fractionation.
  • Introduce penMRT, a Monte Carlo (MC) engine for multi-scale, full dose calculations in MRT.

Main Methods:

  • PenMRT employs the PENELOPE MC code, adapted for voxelized patient CT-scan geometries.
  • Features adaptive micrometric dose grids and dynamic memory allocation for efficient simulations.
  • Incorporates source replication and OpenMPI parallelization to enhance calculation speed for clinical use.

Main Results:

  • PenMRT demonstrated reliability for complex MRT irradiation conditions.
  • Benchmarking against PENELOPE and Gate MC codes showed good agreement, with minor differences in valley regions (1-7.5%).
  • Source replication approach validated with underestimation below 0.6% in low-dose areas.

Conclusions:

  • PenMRT calculations for microbeam arrays showed good agreement (0-8% difference) with literature values for peak-to-valley dose ratios.
  • Generated high-resolution dose maps and dose-volume histograms (DVHs) for cross-fired microbeams.
  • Provides advanced metrics for analyzing complex MRT treatment plans, advancing spatially fractionated radiation therapy.