[Iridoids of wine-processed Corni Fructus].

Area of Science:

• Natural Product Chemistry
• Phytochemistry
• Organic Chemistry

Background:

• Corni Fructus is a traditional medicinal herb with a rich history of use.
• Iridoid glycosides are a significant class of secondary metabolites found in plants, known for diverse biological activities.
• Previous research has identified various compounds from Corni Fructus, but exploration of wine-processed extracts remains less comprehensive.

Purpose of the Study:

• To isolate and characterize chemical constituents from the water extract of wine-processed Corni Fructus.
• To identify novel and known iridoid glycosides for further pharmacological investigation.
• To contribute to the understanding of the chemical diversity within Corni Fructus.

Main Methods:

• Extraction of secondary metabolites from wine-processed Corni Fructus using water.
• Separation and purification of compounds utilizing various column chromatography techniques.
• Structural elucidation of isolated compounds through comprehensive spectroscopic analyses (e.g., NMR, MS).

Main Results:

• Isolation of a new iridoid glycoside, designated as cornuside HMF A (1).
• Identification of nine known iridoid glycosides: 7-dehydrologanin (2), sweroside (3), 7β-O-methylmorroniside (4), 7α-O-methylmorroniside (5), 7β-O-ethylmorroniside (6), 7α-O-ethylmorroniside (7), cornuside (8), sarracenin (9), and loganin (10).
• The chemical structures were confirmed by detailed spectroscopic data interpretation.

Conclusions:

• The study successfully identified ten iridoid glycosides, including one novel compound, from the wine-processed Corni Fructus water extract.
• The findings highlight the potential of wine processing as a method to modify or enhance the phytochemical profile of Corni Fructus.
• The isolated compounds, particularly the new cornuside HMF A, warrant further investigation for their potential therapeutic applications.