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Updated: Sep 28, 2025
Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
Published on: July 5, 2024
Ovarian drilling down-regulates endometrial nuclear factor-κB p65 expression in women with PCOS: A prospective
Nur Dokuzeylül Güngör1, Kağan Güngör2, Arzu Yurci3
1Bahçeşehir University, Medical Park Göztepe Hospital, Clinic of Reproductive Endocrinology and In Vitro Fertilization, İstanbul, Turkey.
Objective:
To investigate the impact of laparoscopic ovarian drilling (LOD) on the expression of endometrial NFκB p65 (Rel A) in women with clomiphene-resistant polycystic ovary syndrome (PCOS).
Materials And Methods:
The study group comprised 25 normal-weight women with PCOS undergoing LOD and 14 control women without PCOS. Endometrial NF-κB p65 levels evaluated before and after LOD following immunohistochemical staining. The semiquantitative method was used to evaluate the intensity of NF-κB p65 levels. NF-κB p65 was found to higher in the endometrium of patients with PCOS compared to controls. LOD leads to significant down-regulation in endometrial NF-κB p65 expression. NF-κB p65 expression of PCOS and fertile control were similar after LOD. After LOD, H-score values decreased approximately 3-fold. The H-score of the control subjects was lower than the preoperative and postoperative H-score values of the control women with ovarian cyst.
Results:
Expression of endometrial NF-κB p65 did not change following ovarian cystectomy. The laterality of the ovarian cyst did not cause any change in preoperative H-score values.
Conclusion:
By downregulating the endometrial NF-κB p65 expression LOD improved physiological inflammation in women with PCOS.
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