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Homocysteine as a marker for predicting disease severity in patients with COVID-19

Adem Keskin1, Goksenin U Ustun2, Recai Aci2

  • 1Department of Medicine Biochemistry, Aydin Adnan Menderes University Institute of Health Sciences, Aydin, 09100, Turkey.

Biomarkers in Medicine
|March 28, 2022
PubMed

Insights

Homocysteine levels can predict COVID-19 severity. This study found homocysteine, along with D-dimer and monocyte/lymphocyte ratio (MLR), effectively indicates disease progression in COVID-19 patients.

Area of Science:

  • Medical research
  • Biomarker analysis
  • Infectious disease diagnostics

Background:

  • Elevated homocysteine levels have been implicated in various inflammatory conditions.
  • Predicting the severity of COVID-19 is crucial for patient management and resource allocation.

Purpose of the Study:

  • To investigate the potential of homocysteine levels as a prognostic marker for COVID-19 severity.
  • To evaluate the diagnostic performance of homocysteine, D-dimer, and monocyte/lymphocyte ratio (MLR) in COVID-19 patients.

Main Methods:

  • A cohort study including 117 COVID-19 patients and 34 non-COVID-19 controls.
  • Receiver operating characteristic (ROC) analysis was employed to assess the predictive values of homocysteine, D-dimer, and MLR.
  • Analysis of individual and combined biomarker performance.

Main Results:

  • ROC analysis showed significant AUC values for homocysteine (0.835), D-dimer (0.859), and MLR (0.882) in COVID-19 patients.
  • Combined analysis of homocysteine, MLR, and D-dimer yielded high AUC values: 0.951 (mild disease), 1.000 (severe disease), and 0.967 (overall COVID-19 cohort).

Conclusions:

  • Homocysteine is identified as a significant prognostic parameter for monitoring COVID-19 disease progression.
  • The combination of homocysteine, D-dimer, and MLR offers a highly accurate method for assessing COVID-19 severity.

Keywords:
COVID-19D-dimerdisease severityhomocysteineinflammationmonocyte lymphocyte ratiopersonalized COVID-19 managementpredictive medicinetargeted prevention

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