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Updated: Sep 28, 2025
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Chemoenzymatic approaches to plant natural product inspired compounds
Rebecca Roddan1, Eve M Carter1, Benjamin Thair1
1Department of Chemistry, University College London, Christopher Ingold Building, London WC1H 0AJ, UK. h.c.hailes@ucl.ac.uk.
Abstract:
Covering: 2003 up to the end of 2021Complex molecules produced by plants have provided us with a range of medicines, flavour and fragrance compounds and pesticides. However, there are challenges associated with accessing these in an economically viable manner, including low natural abundance and the requirement for complex multi-step synthetic strategies. Chemoenzymatic approaches provide a valuable alternative strategy by combining traditional synthetic methods with biocatalysis. This review highlights recent chemoenzymatic syntheses towards plant natural products and analogues, focusing on the advantages of incorporating biocatalysts into a synthetic strategy.
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