Molecular Virology of SARS-CoV-2 and Related Coronaviruses

Yu-An Kung1, Kuo-Ming Lee1,2, Huan-Jung Chiang1

  • 1Research Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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