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Related Concept Videos

Antibody Actions01:26

Antibody Actions

1.4K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.4K
Antibody Structure01:10

Antibody Structure

61.5K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
61.5K
Antibody Structure and Classes01:25

Antibody Structure and Classes

5.2K
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
5.2K
Humoral Immune Responses01:36

Humoral Immune Responses

77.5K
Overview
77.5K

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Related Experiment Video

Updated: Sep 28, 2025

Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
09:07

Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations

Published on: August 22, 2019

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Tackling variants with antibodies.

Elizabeth H Aitken1, Stephen J Rogerson1

  • 1Department of Infectious Diseases, Department of Microbiology and Immunology, at the Doherty Institute, University of Melbourne, Melbourne, Australia.

Elife
|March 28, 2022
PubMed
Summary
This summary is machine-generated.

Antibodies that target the malaria parasite protein can recognize multiple protein variants. This finding may help develop new vaccines to protect pregnant women from placental malaria.

Keywords:
P. falciparumPlacental malariaVAR2CSAblocking antibodyimmunologyinfectious diseaseinflammationmalariamicrobiologypregnancyvaccinevariant

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Vaccine Development

Background:

  • Placental malaria, caused by *Plasmodium falciparum* infection, poses significant risks to pregnant women and their infants.
  • The parasite protein PfP2 varies among strains, complicating vaccine design and therapeutic strategies.
  • Current research focuses on identifying conserved targets within the PfP2 protein to elicit broad immune responses.

Discussion:

  • Antibodies generated against the PfP2 protein demonstrate cross-reactivity with multiple parasite variants.
  • This broad recognition suggests that the targeted epitopes are conserved across different PfP2 strains.
  • Understanding these conserved regions is crucial for designing effective malaria vaccines.

Key Insights:

  • The study identifies conserved epitopes on the PfP2 protein recognized by naturally acquired antibodies.
  • These findings highlight the potential of PfP2 as a vaccine candidate antigen.
  • Broadly neutralizing antibodies could overcome strain-specific variations in placental malaria.

Outlook:

  • Further research should focus on characterizing the specific epitopes targeted by these antibodies.
  • This knowledge can guide the rational design of subunit vaccines for placental malaria.
  • Clinical trials evaluating PfP2-based vaccines are warranted to assess their efficacy in pregnant women.