[MANAGEMENT RECOMMENDATIONS FOR DIRECT ORAL ANTICOAGULANTS (DOACs) ANTI Xa AND ANTI IIa]

Area of Science:

• Cardiology
• Pharmacology
• Internal Medicine

Background:

• Direct oral anticoagulants (DOACs) have revolutionized antithrombotic therapy over the past 15 years.
• DOACs offer advantages including ease of use and reduced bleeding risk, particularly intracranial hemorrhage.
• They are now first-line agents for atrial fibrillation and venous thromboembolic disease.

Purpose of the Study:

• To provide guidance for healthcare professionals on the appropriate use of DOACs.
• To highlight the importance of in-depth knowledge of DOAC characteristics and indications.
• To assist general practitioners in daily DOAC management based on current evidence and expert experience.

Main Methods:

• This position paper synthesizes current evidence and expert consensus.
• It draws upon the collective experience of a group of anticoagulation specialists in Argentina.
• The paper aims to inform clinical decision-making for DOAC therapy.

Main Results:

• DOACs are not universally applicable; patient-specific factors and disease indications must be considered.
• Different DOACs possess distinct characteristics requiring careful selection.
• Expert knowledge is essential for optimizing DOAC therapy and patient outcomes.

Conclusions:

• A comprehensive understanding of DOACs is mandatory for effective patient management.
• General practitioners require updated knowledge to navigate the complexities of DOAC prescribing.
• The evolving landscape of anticoagulation necessitates continuous professional development in DOAC therapy.