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Implications of COVID-19 on Thrombotic Profile of Severely Affected Patients

Swati Srivastava1, Iti Garg1, Vikas Dogra2

  • 1Defence Institute of Physiology and Allied Science, Timarpur, India.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
|March 28, 2022
PubMed

Insights

COVID-19 infection significantly impacts blood clotting, with severe cases showing higher fibrinogen and D-dimer levels. These coagulopathy markers are linked to increased disease severity and mortality in patients.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Hematology

Background:

  • Coronavirus disease 2019 (COVID-19) became a global pandemic in 2020.
  • Thrombotic events are frequently associated with COVID-19 severity.
  • Coagulation parameters influence clinical prognosis in COVID-19 patients.

Purpose of the Study:

  • To investigate the relationship between COVID-19 severity and various thrombotic parameters.
  • To analyze coagulation and anticoagulant levels in relation to COVID-19 infection severity.

Main Methods:

  • Retrospective study of 383 COVID-19 patients categorized by infection severity (severe, moderate, mild).
  • Measurement and analysis of thrombotic parameters (fibrinogen, D-dimer, prothrombin time) and anticoagulant levels (protein S) in 70 patients.

Main Results:

  • Severe and moderate COVID-19 cases showed elevated fibrinogen, D-dimer, and prothrombin time compared to mild cases.
  • Approximately 70% of severe/moderate patients had high fibrinogen, and 60.41% of severe patients had elevated D-dimer.
  • Nonsurvivors exhibited higher thrombotic parameters than survivors, with 91% of severe patients having low protein S levels.

Conclusions:

  • COVID-19 infection significantly disrupts the blood coagulation cascade.
  • Coagulopathy in COVID-19 is associated with increased disease severity and mortality.
  • Monitoring thrombotic parameters is crucial for managing severe COVID-19 cases.
Abstract

Keywords:
Coronavirus disease 2019D-dimerFibrinogenIndian populationSevere acute respiratory syndrome coronavirus 2Thrombosis

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