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Updated: Sep 28, 2025

Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues
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A Small Dose Can Cause a Major Problem.

Pooja Patel1,2,3,4, Adriana Yates Munar4, George Michel4

  • 1Emergency Department, VA Medical Health Care System, Milwaukee, USA.

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|March 29, 2022
PubMed
Summary
This summary is machine-generated.

Baclofen, a muscle relaxant, can cause toxicity in patients with kidney failure. This case highlights the importance of careful medication review and examination in patients with renal dysfunction.

Keywords:
baclofenbaclofen toxicityckddialysisdrug overdosemultivessel coronary artery disease (mvcad)overdose preventionpain controlsevere peripheral arterial diseaseside effects of medical treatment

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Area of Science:

  • Pharmacology
  • Nephrology
  • Clinical Toxicology

Background:

  • Baclofen is a widely used muscle relaxant and gamma-aminobutyric acid agonist.
  • Its efficacy and low addiction potential have made it a preferred choice for muscle spasms.
  • Renal metabolism of baclofen poses a significant risk for patients with kidney dysfunction.

Observation:

  • A case of baclofen toxicity is presented in a patient undergoing hemodialysis.
  • The patient exhibited symptoms consistent with baclofen overdose after a 10 mg dose.
  • Thorough patient history and physical examination were crucial in identifying the toxicity.

Findings:

  • Baclofen toxicity can occur even at low doses in patients with renal failure.
  • Impaired kidney function significantly increases the risk of adverse drug events.
  • Close monitoring of renal function is essential for patients on baclofen.

Implications:

  • This case underscores the critical need for vigilant medication management in patients with renal impairment.
  • Healthcare providers should be aware of baclofen's renal excretion pathway and toxicity risks.
  • Early recognition and intervention are vital to prevent severe complications, including death.