Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Resting-state EEG reveals slowing and altered functional connectivity in children and young adults with severe chronic kidney disease.

Clinical neurophysiology practice·2026
Same author

From network to needle: Integrating structural and functional connectivity for DBS.

Brain stimulation·2026
Same author

Amsterdam Local Field potential Analysis (ALFA) toolbox: an open source software package for deep brain stimulation research.

Brain stimulation·2026
Same author

The role of lipids in neuromodulation for psychiatric disorders: A narrative review.

Translational psychiatry·2026
Same author

[Should carpal tunnel syndrome treatment start with surgery or an injection?]

Nederlands tijdschrift voor geneeskunde·2026
Same author

Technical note: Movement-related artifacts in local field potential signals may influence adaptive deep brain stimulation.

Brain stimulation·2026

Related Experiment Video

Updated: Sep 28, 2025

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.2K

Thalamic local field potentials recorded using the deep brain stimulation pulse generator.

A W G Buijink1, D A Piña-Fuentes1, M J Stam1

  • 1Department of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.

Clinical Neurophysiology Practice
|March 29, 2022
PubMed
Summary
This summary is machine-generated.

Researchers recorded thalamic brain activity in an essential tremor patient using a deep brain stimulation device. This demonstrates the potential for adaptive deep brain stimulation to personalize treatment for movement disorders.

Keywords:
AdaptiveClosed-loopDeep brain stimulationEssential tremorTremor

More Related Videos

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.0K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.6K

Related Experiment Videos

Last Updated: Sep 28, 2025

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.2K
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.0K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.6K

Area of Science:

  • Neuroscience
  • Biomedical Engineering

Background:

  • Essential tremor (ET) is a common movement disorder treated with deep brain stimulation (DBS).
  • Limitations of current DBS include increasing stimulation needs, side effects, and tolerance.
  • Novel sensing-enabled DBS devices allow for LFP recording, enabling adaptive DBS algorithms.

Observation:

  • Thalamic local field potential (LFP) activity was recorded using a sensing-enabled DBS pulse generator (Medtronic Percept PC).
  • Tremor-related activity at 3.8 Hz and its harmonic was observed in the vim nucleus during motor tasks.
  • Coherence analysis confirmed the link between peripheral tremor and thalamic LFP signals.

Findings:

  • This is the first report of tremor-related thalamic activity recorded via an implanted DBS system.
  • The recorded LFP activity correlated with tremor frequency and its harmonics.
  • Coherence between peripheral tremor and thalamic LFP was established.

Implications:

  • Sensing-enabled DBS systems offer potential for real-time monitoring of neurological activity.
  • This technology could pave the way for adaptive DBS algorithms to personalize ET treatment.
  • Further research is needed to validate the clinical utility of these closed-loop systems.